El gigante

 El Gigante  is a towering behemoth, created from humans that were exposed to Las Plagas parasites, and through an unknown method, grew to an immense size, acquiring great strength and brutality to compensate for their loss of higher reasoning.

It could be that the parasite in El Gigante could have caused an extreme growth spurt which increased the bone growth as well as the muscle and skin growth, but it isn't confirmed. These monsters have high stamina and will use their vast size and bulk to choke, crush, kick, charge and punch smaller prey. The only weak point on El Gigante is the accordingly overgrown Plaga attached to its spine. When the Plaga is destroyed, so is El Gigante.